bueno muchacho buscando logre encontrar una magnifica solucion que si funciona en ie y mozilla
function $(id){
return document.getElementById(id);
}
function init()
{
shortcut("Ctrl+F",function()
{
$('nombreFactura').focus();
});
shortcut("Ctrl+R",function()
{
$('nombreD').focus();
});
shortcut("Ctrl+D",function()
{
$('nombreC').focus();
});
shortcut("Ctrl+G",function()
{
guardarEncomienda();
});
}
function shortcut(shortcut,callback,opt) {
//Provide a set of default options
var default_options = {
'type':'keydown',
'propagate':false,
'target':document
}
if(!opt) opt = default_options;
else {
for(var dfo in default_options) {
if(typeof opt[dfo] == 'undefined') opt[dfo] = default_options[dfo];
}
}
var ele = opt.target
if(typeof opt.target == 'string') ele = document.getElementById(opt.target);
var ths = this;
//The function to be called at keypress
var func = function(e) {
e = e || window.event;
//Find Which key is pressed
if (e.keyCode) code = e.keyCode;
else if (e.which) code = e.which;
var character = String.fromCharCode(code).toLowerCase();
var keys = shortcut.toLowerCase().split('+');
//Key Pressed - counts the number of valid keypresses - if it is same as the number of keys, the shortcut function is invoked
var kp = 0;
//Work around for stupid Shift key bug created by using lowercase - as a result the shift+num combination was broken
var shift_nums = {'1':'!','2':'@','3':'#','4':'$','5':'%','6':'^',' 7':'&','8':'*','9'
','0':')','-':'_',
'=':'+',';':':',':':'<','.':'>','/':'?','\\':'|'
}
//Special Keys - and their codes
var special_keys = {
'esc':27,
'escape':27,
'tab':9,
'space':32,
'return':13,
'enter':13,
'backspace':8,
'scrolllock':145,
'scroll_lock':145,
'scroll':145,
'capslock':20,
'caps_lock':20,
'caps':20,
'numlock':144,
'num_lock':144,
'num':144,
'pause':19,
'break':19,
'insert':45,
'home':36,
'delete':46,
'end':35,
'pageup':33,
'page_up':33,
'pu':33,
'pagedown':34,
'page_down':34,
'pd':34,
'left':37,
'up':38,
'right':39,
'down':40,
'f1':112,
'f2':113,
'f3':114,
'f4':115,
'f5':116,
'f6':117,
'f7':118,
'f8':119,
'f9':120,
'f10':121,
'f11':122,
'f12':123
}
for(var i=0; k=keys[i],i<keys.length; i++) {
//Modifiers
if(k == 'ctrl' || k == 'control') {
if(e.ctrlKey) kp++;
} else if(k == 'shift') {
if(e.shiftKey) kp++;
} else if(k == 'alt') {
if(e.altKey) kp++;
} else if(k.length > 1) { //If it is a special key
if(special_keys[k] == code) kp++;
} else { //The special keys did not match
if(character == k) kp++;
else {
if(shift_nums[character] && e.shiftKey) { //Stupid Shift key bug created by using lowercase
character = shift_nums[character];
if(character == k) kp++;
}
}
}
}
if(kp == keys.length) {
callback(e);
if(!opt['propagate']) { //Stop the event
//e.cancelBubble is supported by IE - this will kill the bubbling process.
e.cancelBubble = true;
e.returnValue = false;
//e.stopPropagation works only in Firefox.
if (e.stopPropagation) {
e.stopPropagation();
e.preventDefault();
}
return false;
}
}
}
//Attach the function with the event
if(ele.addEventListener) ele.addEventListener(opt['type'], func, false);
else if(ele.attachEvent) ele.attachEvent('on'+opt['type'], func);
else ele['on'+opt['type']] = func;
}
esta buenisimo
Solo puedo decirles que en los años que llevo en esto, no he visto que se deshabilite en javascript la secuencia del ALT - F4. 
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