Excelente gracias lo probe y me quedo asi:
  Cita:  string cmdPy = "C:/Python34/python.exe";
            string argv = "C:/Python34/hola.py";
 
            ProcessStartInfo start = new ProcessStartInfo();
            start.FileName = cmdPy;
            start.Arguments = argv;
            start.UseShellExecute = false;
            start.RedirectStandardOutput = true;
            using (Process process = Process.Start(start))
            {
                using (StreamReader reader = process.StandardOutput)
                {
                    string result = reader.ReadToEnd();
                    //Console.Write(result);
                    this.Label1.Text = result;
                }
            }
    Pero me quede con: 
 Cita:              int x = 1;
            int y = 2;
 
            var ipy = Python.CreateRuntime();
            var path = Server.MapPath("~/App_Script");
            var fullpath = Path.Combine(path, "Operaciones.py");
 
            dynamic op = ipy.UseFile(fullpath);
            this.Label1.Text = op.sumar(x, y).ToString();